World No. 1 Rafael Nadal and defending champion Andy Murray joined four-time winner Andy Roddick, second seed Novak Djokovic and Marin Cilic on the scrapheap at the Aegon Championships.

Rafael Nadal was defeated by Feliciano Lopez 7-6(5), 6-4 in one hour and 52 minutes. It was Nadal's first defeat since he lost to Andy Roddick in Miami on April 2, after which he embarked on a 24-match unbeaten sequence.

"He played well," said Nadal. "I think his serve was very good and from the baseline he had very good slice. I just [want to] congratulate him. I think he's playing well and I wish him best of luck to win the tournament."

"I feel ready to go back home and enjoy a little bit with my family," Nadal, who showed no sign of the leg muscle injury that caused a pre-Wimbledon scare on Thursday, told reporters after his 24-match winning streak came to an end.

"It's going to be a positive thing to enjoy a little bit of Mallorca weather, have dinner with friends and maybe play some golf. It's going to be very positive to help me go to Wimbledon with good motivation."


Looking ahead to Wimbledon, Nadal admitted he hoped he had got enough grass court practise.

"I think I going to have a few days next week at Wimbledon to practice," said Nadal. "I [have] played a lot of matches the last few months. My feeling was not bad today, so that's positive. Next week in Wimbledon I [am] going to have more time to practice and to adjust my serve, backhand and movements on the grass."

This was Lopez's first win over Nadal since October 2003 at the Davidoff Swiss Indoors in Basel.

"Besides my serve, I think I played very solid," said Lopez. "[I was] consistent from the baseline, trying to be aggressive. I knew that that was [the] only way to have a chance today, and I did it. I'm so happy for that."

Lopez will play Fish in the semi-finals after the American returned to court for a second time on Friday to record a 6-4 6-4 win against Michael Llodra.

Defending champion, Andy Murray was defeated by Mardy Fish 6-4, 1-6, 7-6(2). The match was suspended on Thursday night due to bad light when Fish packed away his rackets and walked off at 3-3 in the deciding set.

"It wasn't particularly good, few rallies, lots of mistakes," Murray told reporters after his brief appearance on center court on Friday. "Today was a bit of a shoot-out. I played two or three bad points and lost the match."

Murray was furious because of the decision to stop the match and he said it's "ridiculous". Later he said that he had received an apology from tournament supervisor Tom Barnes.

"I wasn't annoyed about the light so much as the fact that I wasn't consulted," Murray said.

But despite his lack of exposure to grass, he refuses to dampen his ambitions for the All England Club.

"I'd have liked to have had a couple more matches, but I've gone into Wimbledon in previous years and played well despite not having played many games," he said.

"I'm sure that come Wimbledon I'll be doing a lot better than I was here, having had 10 days more playing on the surface.

"Whether everybody thinks I'm going to win Wimbledon or not, I'll try my best to win. I have a chance of doing it if I play very well."

Rafael Nadal and Andy Murray knocked out of Queen's Club